• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Composition of dietary supplement, comprising - (A) at least one agent that promotes the synthesis of ATP and/or creatine phosphate. - (B) at least one antioxidant to reduce or eliminate free radicals in at least one pathway and normalize the oxidative stress balance, improving cellular mitochondrial function. - (C) at least one agent to normalize or maintain normal neurotransmitter function; protein synthesis; psychological function and normal muscle contraction, - (D) at least one agent to normalize or maintain production of Serotonin, Melatonin and Niacin in the human body. Application in the normalization of the alteration or deterioration of the neurological function and normal function of the mitochondrial structure in the human body, improving the overall energy performance, concentration and resistance to physical exertion, contributing to improve the state of mind in situations of stress, contributing to minimize side effects in anti-cholesterolemia treatments with stainas. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2668082A1
    申请号:ES201631322
    申请日:2016-10-13
    公开日:2018-05-16
    发明作者:Miguel Ángel PÉREZ LÓPEZ；Rubén MONLEÓN SANCHO
    申请人:Ingenius Biotech SL；
    IPC主号:
    专利说明:

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    DESCRIPTION
    Composition of dietary supplement Object of the invention
    Composition of dietary supplement, comprising:
    • (A) at least one agent that promotes the synthesis of ATP and / or creatine phosphate in the body,
    • (B) at least one antioxidant to reduce or eliminate free radicals in at least one pathway in the
    body and normalize the balance of oxidative stress, improving cellular mitochondrial function,
    • (C) at least one agent to normalize or maintain normal neurotransmitter function, synthesis
    normal protein, psychological function and normal muscle contraction in the body,
    • (D) at least one agent to normalize or maintain production of Serotonin, Melatonin and Niacin in
    the human body.
    And also usual excipients and components necessary for its formulation as a dietary supplement.
    The dietary supplement component, object of the present invention, has applications such as the normalization of the alteration or deterioration of neurological function and the normal function of the mitochondrial structure in the human body, improving overall energy efficiency, concentration and resistance to physical exertion, contributing to improve mood in stressful situations, as well as contributing to minimizing the side effects in anti-cholesterolemia treatments with stains.
    Background of the invention
    The existence of nutritional compositions is known, for example, to reduce physical and mental fatigue, to enhance and improve activity, promote muscle performance, increase energy substrates, contribute to the improvement of antioxidant defenses for example, for example in DE10326822 describes a dietary supplement comprising NADH, L-carnitine, Coenzyme Q10, L-carnosine, succinic acid, ascorbic acid, bioflavonoids and / or its derivatives, which also includes a pharmaceutical preparation comprising the dietary supplement and excipients.
    Activity: Antiarteriosclerotic and Antiasmatic.
    Another nutritional supplement composition is described in patent P201001081 which comprises NADH and / or NAD +, coenzyme Q10, vitamin C (ascorbic acid), serine and / or phosphoserine, and usual excipients necessary for its formulation, particularly advantageous for professional drivers and people They usually take drugs that have drowsiness, as the main side effect.
    Patent ES2038603 describes the use of oligopeptides for the treatment of brain disorders, especially insomnia and depressions, whose formulation includes, among others, a residue derived from tryptophan, 5-hydroxy-L-tryptophan or one of the L - amino acids: glycine, alanine, serine, threonine, cysteine, asparagine methionine, aparaginic acid, glutamine, glutamic acid, histidine, lysine and proline.
    The patent ES2087027, refers to nutritional supplements that confer thermogenic character to foods or diets that contain them when ingested by people, causing a greater part of the energy of these foods to be lost as heat (thermogenesis), being essentially constituted by one or more thermogenic amino acids, selected from L-tryptophan, L-methionine, L-threonine, or combinations with the rest of essential amino acids or their precursors or derivatives selected from their esters, neutral salts, protein hydrolyzed synthetic polymers or complexes of the cited amino acids or mixtures rich in said amino acids.
    Patent ES2190069 refers to solid compositions suitable for oral administration containing an alkanoyl-L-carnitine magnesium citrate, to provide stable and non-hygroscopic salts of lower alkanoyl L-carnitines that have nutritional efficacy and / or or therapeutic enhanced with respect to its counterparts in internal salts.
    In the ES2284900 patent, a dietary or health supplement is described which comprises an effective amount of a micronutrient selected from the group consisting of complexes of ubiquinol phosphate derivatives, ascorbic acid, retinol, tocotrienol, tocopherol and mixtures thereof administered with an acceptable vehicle, in which the micronutrient is the reaction product of (a) one or more phosphate derivatives of
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    ubiquinol, ascorbic acid, tocotrienol, retinol, tocopherol and mixtures thereof and (b) one or more complexing agents selected from the group consisting of amphoteric surfactants, cationic surfactants, amino acids having nitrogen functional groups and proteins rich in these amino acids
    Patent ES2311297, refers to an amino acid complement for dialysis patients for the treatment of hypoalbuminemia, comprised in the formulation of each tablet L-histidine, L-isoleucine, L-leucine, L-lysine, L-methionine, L- phenylalanine, L-threonine, L-Tryptophan, L-tyrosine and L-valine.
    US2002182196, refers to a composition for the normalization of the alteration or deterioration of neurological function in the human body, comprising effective amounts of: (A) at least one agent that promotes the synthesis of ATP and / or creatine phosphate in the body; (B) at least one antioxidant to eliminate free radicals in at least one pathway in the body; (C) at least one agent to normalize or maintain membrane function and structure in the body; (D) at least one agent to normalize or maintain normal neurotransmitter function in the body; (E) at least one agent for the cortisol action below the regulation; and (F) at least one agent for suppressing the activation of apoptosis pathways in the human body.
    Dietary supplement
    It is a dietary supplement composition with applications such as stimulating / improving / increasing the production of Serotonin and Adenosine Triphosphate (ATP) that occurs naturally thereby increasing overall energy efficiency, concentration and resistance to physical exertion, improving mood in stressful situations to
    • reduce physical and mental fatigue,
    • improve activity,
    • improve recovery of activity,
    • promote muscle performance,
    • increase energy substrates and
    • contribute to the improvement of antioxidant defenses (ie reduce oxidative stress or
    lipid peroxidation, preserve antioxidants in the serum), to improve mood, including:
    (A) at least one agent that promotes the synthesis of ATP and / or creatine phosphate in the body;
    (B) at least one antioxidant to reduce or eliminate free radicals in at least one pathway in the body and normalize the balance of oxidative stress, improving cellular mitochondrial function.
    (C) at least one agent to normalize or maintain normal neurotransmitter function, normal protein synthesis, psychological function and normal muscle contraction in the body
    (D) at least one agent to normalize or maintain production of Serotonin, Melatonin and Niacin in the human body.
    (A) - comprises one or more members selected from the group consisting of Nicotin Adenine Dinucleotide Hydride (NADH) and / or NAD +, phosphatidyl serine, B vitamins, oral creatine, cytidine-5'-diphosphate, lipoic acid and alpha ribose; phosphatidylserine.
    The NADH and / or NDA + molecule: called nicotinamide adenine dinucleotide, abbreviated NAD +, is a coenzyme found in all living cells. The compound is a dinucleotide, as it consists of two nucleotides linked through their phosphate groups, with one nucleotide containing an adenine base and the other containing nicotinamide.
    In human metabolism, NAD + or NADH is involved in redox reactions, carrying electrons from one reaction to another. Coenzyme is found in two forms in cells: NAD +, which is an oxidizing agent that accepts electrons from other molecules and is reduced to the formation of NADH, which can then be used as a reducing agent to donate electrons.
    These electron transfer reactions are the main function of NAD + / NADH. However, it is also used in other cellular processes, in particular as a substrate of enzymes that add or remove chemical groups from proteins. Due to the importance of these functions, the enzymes involved in the metabolism of NAD + / NADH are targets for drug discovery.
    In our body, NAD + / NADH can be synthesized from simple building blocks (de novo) from amino acid tryptophan or aspartic acid.
    Alternatively, the most complex components of coenzymes are taken from foods such as vitamin called Niacin or vitamin B3.
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    Other alternative routes with great antioxidant power are: Lipoic Acid, Phosphocreatine, Alpha Ribose that also intervenes in the synthesis of cellular energy (ATP),
    NADH is directly involved in the body's immune cell defense system.
    NADH, biologically known as coenzyme 1 (since it is the most important co-enzyme, also known as Co-E1), is therefore necessary for thousands of biochemical reactions in the body and is found naturally in all living cells, according to It is cited in the summary of the academic article:
    • Review focusing on characterization, efficacy, safety, use and promising areas for oral NADH * (Clause Kelley, MPH, MS, HD, RD, CDE) , CNSD ** Professor Clinical Nutrition Science; Southern California University of Health Sciences, Whittier CA
    As a dietary supplement NADH is currently marketed to help increase energy and vitality in the human body. Nutritional compositions containing NADH can also help in the fight against the effects of disorders such as fibromyalgia, which is a physical disorder that makes the sensory system more sensitive to physical and environmental stimuli such as pain, and cures with a neurotransmitter deficit, as cited in the summary of the following academic article:
    • Psychobiochemistry (stress, anxiety and depression) in fibromyalgia: Pedro T. Sánchez, Julia M. Sánchez, Miguel de Lamo, Gema Peiró,
    To relieve the symptoms of certain energy disorders such as fatigue, chronic fatigue syndrome in particular, which is often related to stress, and which is defined as a condition in which a patient has persistent fatigue not attributable to any other cause as citation in the summaries of the following academic articles:
    • Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome e A randomized, controlled, double-blind trial (Effect of coenzyme Q10 supplementation with nicotinamide adenine dinucleotide on maximum heart rate after the stress test in chronic fatigue syndrome): Jesus Castro- Marrero a, *, 1, Naia Saez-Franca sb, d, 1, María Jose Segundo c, Natalia Calvo, Monica Faro a, Luisa Aliste a, Tomas Fdez from Seville to, Jose Alegre
    • Does Oral Coenzyme Q 10 Plus NADH Supplementation Improve Fatigue and Biochemical Parameters in Chronic Fatigue Syndrome (Does the oral supplementation of coenzyme Q10 improve fatigue and biochemical parameters in chronic fatigue syndrome ): Jesús Castro-Marrero, Mario D. Cordero, María J. Segundo, Naia Sáez-francás, Natalia Calvo, Lourdes Román -Malo, Luisa Aliste, Paula Riera Ríos, Tomás Fdez. Of Seville, José Alegre-Martín.
    (B) one or more members selected from the group consisting of Co-Enzyme Q10, Ubiquinona, Ubiquinol; Rivoflavin; Selenium; vitamin C; Vitamin E; Zinc
    Coenzyme Q10, is also known as ubiquinone, ubidecarenone, coenzyme Q, and sometimes abbreviated as CoQ, CoQ10, Q10, or Q. This compound is a 1,4-benzoquinone compound, where Q refers to the chemical group of quinone and 10 refers to the number of isoprenyl chemical subunits.
    This fat-soluble substance is present in most eukaryotic cells, mainly in the mitochondria. It is a component of the electron transport chain and participates in aerobic cellular respiration, the generation of energy in the form of ATP.
    Due to its ability to transfer electrons and, therefore, act as an antioxidant, CoQ10 is used as a dietary supplement, for example, in the following applications: mitochondrial disorders, heart failure, headaches, cardiac arrest, blood pressure, disease periodontal, depression, Parkinson's disease, as cited in the summaries of the following academic articles:
    • Clinical applications of coenzyme Q10 (Clinical applications of coenzyme Q10): Juan Garrido-Maraver, Mario D Cordero, Manuel Oropesa-Avila, Alejandro Fernandez Vega, Mario De La Mata, Ana Delgado Pavon, Elisabet Alcocer-Gomez, Carmen Perez Calero , Marina Villanueva Paz, Macarena
    Alanis, Isabel De Lavera, David Cotan, Jose A Sanchez-Alcazar.
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    • Does Oral Coenzyme Q 10 Plus NADH Supplementation Improve Fatigue and Biochemical Parameters in Chronic Fatigue Syndrome (Does the oral supplementation of coenzyme Q10 improve fatigue and biochemical parameters in chronic fatigue syndrome ); Jesús Castro-Marrero, Mario D. Cordero, María J. Segundo, Naia Sáez-francás, Natalia Calvo, Lourdes Román-Malo, Luisa Aliste, Paula Riera Ríos, Tomás Fdez. Of Seville, José Alegre-Martín.
    • Lower plasma Coenzyme Q10 in depression; a marker for treatment resistance and chronic fatigue in depression and a risk factor to cardiovascular disorder in that illness (Coenzyme Q10 lower plasma in depression: a marker of treatment resistance and chronic fatigue in depression and a risk factor for cardiovascular disorder in this disease): Michael Maes, Ivanka Mihaylova, Marta Kubera, Marc Uytterhoeven, Nicolas Vrydags, Eugene Bosmans.
    The ubiquinone, or coenzyme Q10, is an essential component of the mitochondria, playing a leading role in the electron transport system as an antioxidant agent by participating in the cellular mechanism of aerobic respiration and contributing with about 95% of body energy. Its deficit would be associated with a deficiency of oxidative phosphorylation and production of mitochondrial ATP, damaging muscle energy metabolism and thus contributing to the development of myopathy and muscle symptoms.
    Statins reduce the reserves of ubiquinone and mevalonate, reflected in reduced concentrations thereof, both at the plasma level and at the level of reserves by 25 to 50%. Coenzyme Q10 supplement has had beneficial effects on symptoms related to statin-mediated myopathy as cited in the summary of the following academic article:
    • Effect of Coenzyme Q10 on Myopathic Symptoms in Patients Treated With Statins: Giuseppe Caso, MD, MSc, PhDa, Patricia Kelly, DOb, Margaret A. McNurlan, PhDa , and William E. Lawson, MD
    Compositions containing both NADH and CoQ10 are also known as a dietary supplement, as indicated because of their ability to deliver energy, mimicking mechanisms of energy production and antioxidant activity that usually occur in the human body.
    Other alternative pathways for energy formation are Rivoflavin or Vitamin B2 as well as vitamins C and E, which together with certain minerals such as Zinc and Selenium are essential cofactors for anti-Redox processes and the formation of ATP.
    (C) comprises one or more antioxidants selected from the following: Magnesium Citrate, vitamin E, magnesium malate; Vitamin C, carnosine, tocotrienols, flavonoids, vinpocetine, selenium, lycopene, creatine, arginine, taurine, cysteine, nicotinamide adenine dinucleotide, resveratrol, ginkgo biloba, oligomeric proanthocyanidins, and phenolic antioxidants.
    Magnesium is a mineral nutrient, currently as an essential cofactor in more than 300 biosynthesis processes in our body, is part of the Mg-ATP complex, is essential for oxidative phosphorylation and has an important implication in energy metabolism, mineral homeostasis, calcium metabolism, and neuromuscular and endocrine function.
    It is also related to protein synthesis, cell mitosis, the normal functioning of the nervous system and muscular contractility. In short, the relationship between dietary magnesium intake and electrolyte balance has been established, contributes to normal energy-producing metabolism, normal neurotransmission and muscle contraction, including heart muscle, normal cell division, bone maintenance normal, the maintenance of normal teeth, and the synthesis of normal proteins, as cited in the summaries of the following academic articles:
    • EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (Technical Commission for Dietary Products, Nutrition and Allergies (NDA); European Food Safety Authority (EFSA), Parma, Italy, EFSA Journal 2009; 7 (9); 1216 Scientific Opinion on the substantiation of health claims related to magnesium and electrolyte balance (ID 238), energy-yielding metabolism (ID 240, 247, 248), neurotransmission and muscle contraction including heart muscle (ID 241, 242), cell division (ID 365 ), maintenance of bone (ID 239), maintenance of teeth (ID 239), blood coagulation (ID 357) and protein synthesis (ID 364) according to Article 13 (1) of Regulation (EC) No 1924/20061 •
    • Is magnesium citrate treatment effective on pain, clinical parameters and functional status in patients with fibromyalgia (Is magnesium citrate an effective treatment in pain, clinical parameters and
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    functional status in fibromyalgia patients ): Selda Bagis, Mehmet Karabiber, Ismet As • Lulu fer Tamer, Canan Erdogan, Ayge Atalay.
    There are other molecules whose action is related or resembles in their function with metabolic processes where Magnesium intervenes such as flavonoids, arginine, cysteine etc. But these have a more particular and defined metabolic role, they do not have the extensive activity and metabolic need of Magnesium.
    (D) comprises one or more members selected from the group consisting of Tryptophan, L-Tryptophan, L-5 hydroxytryptophan; 5-HTP
    Tryptophan is abbreviated Trp or W in the nomenclature of three or one letter respectively. It is one of the 20 essential amino acids for the human body, since the human species is unable to synthesize them by ourselves, so it has to be present in our diet.
    Trp is an apolar, hydrophobic and aromatic amino acid, since it has a ring with conjugated resonant double bonds, which gives the molecule great structural stability and gives off less energy in the reactions in which it participates.
    This aromatic quality is due to its R group (the specific amino acid side chain). Since it is an indole group, with two rings one of six carbons and another of five carbons, both with delocalized bonds.
    Its molecular formula is C11H12N2O2, which gives it a molecular mass of 204.23 u.
    It is essential for the formation of proteins and also its secondary metabolism participates in the synthesis of alkaloids, hormones and pigments. The synthesis of Serotonin and its neuronal concentration depend directly on the Tryptophan concentration.
    Trp is a precursor of these molecules, so if we don't get enough in our diet we can't produce serotonin. Trp is metabolized primarily by two pathways, that of serotonin and the quinurenine pathway.
    In the serotonin pathway, it is an indispensable factor in the secretion of serotonin in the pineal gland. Serotonin is a neurotransmitter that regulates very diverse processes such as sleep, stress or hunger, it is the neurotransmitter of positivism, as cited in the summaries of the following academic articles:
    • Kynurenine pathway pathologies: do nicotinamide and Other pathway co-Factors have Therapeutic Role in Reduction of symptom severity, Including chronic Fatigue syndrome (cFs) and Fibromyalgia (FM). Therapeutic role in reducing the severity of symptoms, including chronic fatigue syndrome (CFS) and Fibromyalgia (FM) ): Adele Blank eld
    • Tryptophan Biochemistry: Structural, Nutritional, Metabolic, and Medical Aspects in Humans. Lionella Palego, 1 Laura Betti, 2.3 Alessandra Rossi, 1 and Gino Giannaccini2, 3
    The quinurenine pathway has the final result of niacin, also called vitamin B3, which we can obtain in cereals or through the catabolism of Trp. Niacin in turn is a precursor of the NADPH and NADH molecules, which are the reservoir of the reducing power of the cell, which will be used to synthesize molecules that require reduction or energy.
    Other active metabolites of Tryptophan are L-5-Hydroxytryptophan and 5-htp, whose metabolic role is similar although its molecular form is different.
    SUMMARY OF THE INVENTION
    The present invention provides a composition comprising different compatible active ingredients, capable of
    • Contribute to restore and / or increase overall energy efficiency, concentration and resistance to physical exertion. Improving mood in stress situations
    • be used as dietary supplements for humans, particularly in situations where a high level of attention and concentration is necessary
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    • restore / stimulate major biochemical pathways that are aimed at energy production and / or for increased attention in the human body, without adverse side effects.
    • to stimulate / improve / increase the production of natural origin Serotonin, thus solving the problem due to the impossibility of oral administration of Serotonin since this route does not cross the blood-brain barrier and its oral administration is totally ineffective
    • to be used as a dietary supplement and nutritional products also in addition to the usual drugs and medications, without having unexpected side effects
    These and also other objects are achieved by the composition of the dietary supplement that is recommended to comprise, as active ingredients:
    (A) at least one agent that promotes the synthesis of ATP and / or creatine phosphate in the body, in a proportion between 1.38 and 2.76% of the overall weight of the composition, comprising one or more selected members from the group consisting of, Nicotin Adenin Dinucleotide Hydride (NADH) and / or NAD +, phosphatidyl serine, B vitamins, oral creatine, citidine-5'-diphosphate, lipoic acid and alpha ribose; phosphatidylserine.
    The preferred selected member is: Nicotin Adenin Dinucleotide Hydride (NADH) and / or NAD +
    (B) at least one antioxidant to reduce or eliminate free radicals in at least one pathway in the body and normalize the balance of oxidative stress, improving cellular mitochondrial function, in a proportion between 13.8 and 27.6% of the overall weight of the composition, comprising one or more members selected from the group consisting of Co-Enzyme Q10, Ubiquinona, Ubiquinol; Rivoflavin; Selenium; vitamin C; Vitamin E; Zinc
    Being the preferred selected member: Co-Enzyme Q10.
    (C) at least one agent to normalize or maintain normal neurotransmitter function; normal protein synthesis; Psychological function and normal muscular contraction in the body, in a proportion between 5.70 and 11.39% of the overall weight of the composition, comprising one or more antioxidants selected from the following: Magnesium Citrate, Vitamin E, Malate magnesium; Vitamin C, carnosine, tocotrienols, flavonoids, vinpocetine, selenium, lycopene, creatine, arginine, taurine, cysteine, nicotinamide adenine dinucleotide, resveratrol, ginkgo biloba, oligomeric proanthocyanidins, and phenolic antioxidants.
    Being the selected member: Magnesium Citrate
    (D) at least one agent to normalize or maintain production of Serotonin, Melatonin and Niacin in the human body, in a proportion between 20.69 and 41.38% of the overall weight of the composition, comprising one or more selected members from the group consisting of Tryptophan, L-Tryptophan; L-5 hydroxytryptophan, 5-HTP.
    Being the preferred selected member: L-Tryptophan
    The composition according to the present invention further comprises usual excipients and components necessary for its formulation as a dietary supplement.
    A dietary supplement, also known as a food supplement or food supplement, is a preparation intended to supplement the diet and provide nutrients, such as vitamins, minerals, fiber, fatty acids or amino acids, which may or may not be consumed in sufficient quantity in The diet of a person. Some countries define dietary supplements as food, while in others they are defined as medicines or natural health products.
    According to the present invention, each of the active ingredients of the composition is essential to show a surprising effect as a dietary (nutritional) supplement due to a synergistic effect of its essential active ingredients and, in particular, due to the addition of L- Tryptophan to the other components, that is, NADH and / or NAD +, Coenzyme Q10 and Magnesium
    It has been observed, in fact, that the composition according to the present invention can positively influence the main processes of natural oxidation-reduction origin, the transfer of electrons to enzymes that act as biocatalysts in these reactions.
    For example, one of these reactions is the hydroxylation of dopamine to give norepinephrine and its prosecution process to give adrenaline as the final product.
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    Adrenaline has a significant sympathomimetic effect, for example, during the emotional crisis or when it is necessary to alert or prepare the body for an emergency situation. In fact, adrenaline acts as a stimulant of the sympathetic system and is capable of producing positive effects on the central nervous system.
    It should be noted that it is not possible to administer adrenaline by oral administration, because it undergoes oxidation and degradation / conjugation during the gastrointestinal passage and in the liver.
    Therefore, it has been found, in accordance with the present invention, that a supplementary diet composition comprising L-tryptophan, NADH or nAd +, Coenzyme Q10 and Magnesium citrate) as active and the essential components, surprisingly It can and significantly promote the natural production of adrenaline and serotonin in the human body, while avoiding unwanted side effects.
    According to the present invention, therefore, the composition comprising L-Tryptophan, NADH and / or NAD +, Coenzyme Q10 and Magnesium Citrate as active and essential ingredients, is advantageously used as a dietary supplement in cases where it is the need to improve and / or energy recovery, for example during a convalescence, fibromyalgia, chronic fatigue syndrome, as cited in the summary of the following academic article:
    • Oxidative stress, mitochondrial dysfunction and, inflammation common events in skin of patients with Fibromyalgia (Benito Sánchez -Dguez, Pedro Bullón, Lourdes Román) -Malo, Fabiola Marín-Aguilar, Elísabet Alcocer-Gómez, Angel M. Carrión, José Antonio Sánchez-Alcazar, Mario D. Cordero.
    In this case, for example, it has been observed that the composition according to the invention acts as a stimulator in cases of weakness, fatigue, fatigue and the like.
    For example, always according to the invention, the composition can be advantageously used as an adjuvant dietary supplement for those people who need special attention, such as patients under treatment with statins, fibromyalgia, chronic fatigue, in carrying out activities and jobs that require high concentration and agility of response and reaction
    Another related use of the composition according to the invention is directed, for example, to the reduction of sleepiness that causes particular drug intake, thus solving a widespread problem.
    For example, those who are forced to take antihistamines suffer very important problems from drowsiness.
    In the market, there are already associations between antihistamine and stimulant drugs; However, the exciting action of the stimulant drug, necessary to contrast the side effect of an antihistamine drug, is difficult to modulate and very often causes a worse side effect, keeping the patient awake too long and thus causing an associated fatigue syndrome. .
    The association of an intake of antihistamine drugs with a dietary supplement according to the present invention, would allow to physiologically modulate the stimulating effect, thus avoiding an excess of response and the presence of additional side effects.
    According to the present invention, the term "association" or "combination" means that the composition according to the invention and the antihistamine (or other existing drug having drowsiness as the main side effect) are administered together in separate forms as different formulations. , or at different times also in separate forms and different formulations or in a single form or formulation,
    The availability of a product capable of inducing a natural and endogenous stimulatory effect, which can effectively contrast the side effect of drowsiness of certain medications, has long been a necessity, especially for those who must drive cars, trucks, trains and airplanes for professional reasons and jobs that require a lot of concentration and agility of response and reaction
    The composition according to the present invention represents a great improvement in dietary supplements designed to act in the restoration / induction of energy in the human body. In fact, the surprising effect of reducing drowsiness while inducing a better feeling of energy will result in an innovative nutritional supplement with respect to existing products, which are active in energy levels, but have no effect on Regarding sleepiness.
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    It should be noted, as already stated above, that the composition according to the invention is capable of inducing a positive response of the human body with respect to sleepiness, without causing adverse side effects of fatigue or the like, such as the response of Body is a kind of "natural", "endogenous" response and is not caused by additional medications.
    Therefore, the suggested use of this dietary supplement is in all cases where an increase / restoration of the body's energy is required, together with a recovery of the levels of care affected by various causes, among which are, by For example, the intake of drugs with adverse side effects related to drowsiness.
    The person skilled in the art will readily understand that he can combine characteristics of different embodiments with characteristics of other possible embodiments, provided that such combination is technically possible.
    Always according to the invention, some examples of compositions containing L-tryptophan, NADH and / or NAD +, coenzyme Q10 and Magnesium Citrate as active ingredients, as indicated in Table 1.
     Active ingredient  Formula 1 Formula 2 Formula 3
     mg mg mg
     L-Tryptophan  300 150 75
     CoQ10  200 100 50
     NADH  20 10 5-7
     Magnesium Citrate  590 295 147-150
     Excipients q.s.p Arox.  100 50 25
    *Table 1
    It is intended that the above formulations are given only as examples of compositions of dietary supplements according to the invention and that it does not represent in any way a limitation of the scope of protection.
    The dietary supplement compositions according to the invention can be formulated in all forms suitable for oral administration, for example tablets, film-coated tablets, sublingual tablets, dispersible tablets, oral dispersible tablets, sachets, capsules, powders, granules, micro- granules, soluble effervescent granules.
    Always according to the invention, dietary supplement compositions can also be formulated in all forms suitable for rectal, nasal administration, or any other suitable administration.
    The information contained in examples, embodiments and tables is part of the description of the invention.
    权利要求:
    Claims (9)
    [1]
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    1. Composition of dietary supplement, characterized by comprising:
    • (A) at least one agent that promotes the synthesis of ATP and / or creatine phosphate in the body, in a
    proportion between 1.38 and 2.76% of the overall weight of the composition
    • (B) at least one antioxidant to reduce or eliminate free radicals in at least one pathway in the
    body and normalize the balance of oxidative stress, improving cellular mitochondrial function, in a proportion between 13.8 and 27.6% of the overall weight of the composition.
    • (C) at least one agent to normalize or maintain normal neurotransmitter function; synthesis
    normal protein; Psychological function and normal muscular contraction in the body, in a proportion between 5.70 and 11.39% of the overall weight of the composition.
    • (D) at least one agent to normalize or maintain production of Serotonin, Melatonin and Niacin in
    the human body, in a proportion between 20.69 and 41.38% of the overall weight of the composition.
    [2]
    2. Dietary supplement composition according to claim 1, characterized in that the component (A) comprises one or more members selected from the group consisting of, Nicotin Adenine Dinucleotide Hydride (NADH) and / or NAD +, phosphatidyl serine, vitamins B, creatine oral, citidine-5'-diphosphate, lipoic acid and alpha ribose; phosphatidylserine.
    [3]
    3. Dietary supplement composition according to the preceding claims, characterized in that the component (A) selected is Nicotin Adenine Dinucleotide Hydride (NADH) and / or NAD +
    [4]
    4. Dietary supplement composition according to the preceding claims, characterized in that component (B) comprises one or more members selected from the group consisting of Co-Enzyme Q10 or Ubiquinone, Ubiquinol, Rivoflavin, Selenium, Vitamin C, Vitamin E, Zinc .
    [5]
    5. Dietary supplement composition according to the preceding claims, characterized in that the component (B) selected is Co-Enzyme Q10 or Ubiquinone.
    [6]
    6. Dietary supplement composition according to the preceding claims, characterized in that the component (C) comprises one or more members selected from the group consisting of Magnesium Citrate, vitamin E, magnesium malate, vitamin C, carnosine, tocotrienols, flavonoids, Vinpocetine, selenium, lycopene, creatine, arginine, taurine, cysteine, nicotinamide adenine dinucleotide, resveratrol, ginkgo biloba, oligomeric proanthocyanidins, and phenolic antioxidants.
    [7]
    7. Dietary supplement composition according to the preceding claims, characterized in that the component (C) selected is Magnesium Citrate.
    [8]
    8. Dietary supplement composition according to the preceding claims, characterized in that the component (D) comprises one or more members selected from the group consisting of Tryptophan, L-Tryptophan, L-5 hydroxytryptophan, 5-HTP.
    [9]
    9. Dietary supplement composition according to the preceding claims, characterized in that the component (D) selected is L-Tryptophan.
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    同族专利:
    公开号 | 公开日
    EP3527082A4|2020-06-03|
    EP3527082A1|2019-08-21|
    ES2668082B1|2019-03-13|
    WO2018069557A1|2018-04-19|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    DE69814834T2|1997-03-27|2004-04-08|Sole, Michael J., Toronto|NUTRITIONAL COMPOSITION TO IMPROVE CELL ENERGY|
    US6964969B2|2001-04-19|2005-11-15|Mccleary Edward Larry|Composition and method for treating impaired or deteriorating neurological function|
    US20060257502A1|2005-05-11|2006-11-16|Jiankang Liu|A combination of mitochondrial nutrients for relieving stress, preventing and improving stress-related disorders|
    US20090017136A1|2007-07-10|2009-01-15|Wayne Gorsek|Formulation to prevent and treat fibromyalgia, depression and other muscle and nervous system disorders|
    US20090104171A1|2007-10-19|2009-04-23|Pardee Joel D|Metabolic Enhancement Therapy|
    ES2635763T3|2010-08-17|2017-10-04|Vitae Natural Nutrition, S.L.|Nutritional Supplement Composition|
    WO2014068499A1|2012-11-02|2014-05-08|Dsm Ip Assets B.V.|Use of tryptophan rich protein hydrolysates|
    JP2016034269A|2014-07-30|2016-03-17|ミネルヴァ リサーチ ラブス リミテッド|Anti-aging antioxidant nutritional supplement for improvement of integumentary system|
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    ES201631322A|ES2668082B1|2016-10-13|2016-10-13|COMPOSITION OF DIETETIC COMPLEMENT|ES201631322A| ES2668082B1|2016-10-13|2016-10-13|COMPOSITION OF DIETETIC COMPLEMENT|
    PCT/ES2017/070629| WO2018069557A1|2016-10-13|2017-09-22|Dietary complement composition|
    EP17860080.5A| EP3527082A4|2016-10-13|2017-09-22|Dietary complement composition|
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